Workshop D: Bridging the Translational Gap for Clinical Success: Modelling Heterogenetic Psychiatric Phenotypes in Behavioural vs Circuit-Based In Vivo Models
Time: 1:00 pm
day: Pre-Conf Day - D
Details:
The need for more human-relevant model systems to predict clinical efficacy of anxiolytics, antipsychotics and more remains fundamental to translating the plethora of preclinical psychiatric drug candidates into phase 1 studies. Moreover, the constraints of behavioural models in predicting clinical efficacy have redirected focus toward exploring the potential of modelling neurological deficits and specific brain circuits. Join this workshop to explore recent preclinical innovation and collaboratively discuss novel ideas to enhance translatability.
Highlights include:
- Leveraging transgenic animal studies to elevate understanding of disease pathophysiology and investigate receptor interactions leading to behavioural traits
- Evaluating the ability of animal behavioural models to model underlying brain circuitry; can they predict anxiolytic and antidepressant effects?
- Exploring to what extent circuit-based approaches have succeeded so far
- Evaluating types of models most suitable for human experimental studies
