Enhancing the Selectivity, Sensitivity & Predictive Validity of Animal Models to Successfully Translate Novel Antidepressant, Antipsychotic & Anxiolytic Therapeutics
Time: 1:01 pm
day: Workshop Day
Details:
With a pressing need for in vivo assays that more accurately predict the effects of antidepressants, antipsychotics and anxiolytics in humans, join this collaborative workshop to benchmark new strategies, from recreating exact phenotypes to optimizing dose selection, to bridge the translational gap.
Highlights Include:
- Leveraging advancements in systems neuroscience: which animal behaviours are meaningful indicators of antipsychotic, antidepressant, or anxiolytic effects?
- Improving predictability: can we find a stimulant that better replicates the disease state and back translate to enhance predictive power?
- Enhancing sensitivity and specificity: how can we refine the model to accurately detect signals from the specific drug being studied while minimizing false positives?
- Informing human dose selection: how can we translate animal efficacy data into accurate clinical dose predictions?
