Zoe Hughes
Vice President Biology & Translational Medicine Gilgamesh Pharmaceuticals
Seminars
Thursday 17th September 2026
Panel Discussion: Ketamine & Rapid Acting Antidepressants: Plasticity, Metabolites & the Next Generation of Therapeutic Innovation
10:30 am
- What emerging preclinical and clinical data reveal about ketamine induced synaptic plasticity as a unifying mechanism for rapid antidepressant effects
- The role of ketamine metabolites, including HNKs, in disentangling efficacy from dissociation and informing more targeted drug design
- Progress toward non dissociative and next generation ketamine derived therapies, and how these may reshape safety, scalability, and patient access
- Lessons from S-ketamine on regulatory pathways, payer expectations, and commercial adoption; and what this means for the broader psychedelic and rapid acting psychiatry landscape
