John Salamone
Board of Trustees Distinguished Professor & Director of Behavioral Neuroscience Professor University of Connecticut
Seminars
Thursday 17th September 2026
Advancing Therapeutics for Apathy: Integrating Dopaminergic & Non Dopaminergic Strategies to Restore Motivation
11:30 am
- Translating animal models of effort-based decision making into clinical insights to better characterize apathy and motivational deficits across neuropsychiatric and neurodegenerative disorders
- Targeting dopaminergic mechanisms, including modulation of dopamine transmission with atypical dopamine transport inhibitors to address apathy‑related motivational dysfunctions
- Exploring non dopaminergic pathways such as adenosinergic mechanisms and other emerging targets that offer complementary routes to restoring motivation
- Building an integrated therapeutic framework that combines dopaminergic and non-dopaminergic strategies to overcome unmet needs in treating apathy and motivational impairments
