Ernest Pedapati
Professor, UC Department of Psychiatry and Behavioral Neuroscience Cincinnati Children’s Hospital
Ernest Pedapati, MD, MS, FAAP is a physician-scientist and Professor in the University of Cincinnati Department of Psychiatry and Behavioral Neuroscience at Cincinnati Children’s, where he co-directs the Neurobehavioral Neurophysiology Laboratory. His clinical and research work focuses on fragile X syndrome, autism, and related neurodevelopmental conditions, using EEG and TMS to measure cortical function, target engagement, and treatment response. An NIH-funded investigator since 2017, including a K23 award, he has spent his career moving those methods from academic studies into trial-grade use. As Co-Founder and Director of Neurophysiology at CinciNeuro, he leads EEG analysis for clinical trials in major brain disorders, backed by more than 30 years of combined neuroscience and software engineering experience.
Seminars
- Using EEG as a sensitive, translational readout of drug-target engagement in small first in human studies across Fragile X, schizophrenia, and other brain disorders
- Demonstrating rapid rescue and normalisation of disease relevant EEG signals following acute dosing and linking these changes to clinically meaningful cognitive outcomes
- Pairing EEG biomarkers with regulatory acceptable endpoints, including NIH Toolbox measures, to strengthen confidence in early proof of concept
- Applying EEG based responder identification to de risk progression into larger Phase 2 and 3 trials across heterogeneous neuropsychiatric populations
