Ernest Pedapati
Professor, UC Department of Psychiatry and Behavioral Neuroscience Cincinnati Children’s Hospital
Ernest Pedapati, MD, MS, FAAP is a physician-scientist and Professor in the University of Cincinnati Department of Psychiatry and Behavioral Neuroscience at Cincinnati Children’s, where he co-directs the Neurobehavioral Neurophysiology Laboratory. His clinical and research work focuses on fragile X syndrome, autism, and related neurodevelopmental conditions, using EEG and TMS to measure cortical function, target engagement, and treatment response. An NIH-funded investigator since 2017, including a K23 award, he has spent his career moving those methods from academic studies into trial-grade use. As Co-Founder and Director of Neurophysiology at CinciNeuro, he leads EEG analysis for clinical trials in major brain disorders, backed by more than 30 years of combined neuroscience and software engineering experience.
Seminars
- Using resting-state and auditory EEG biomarkers to detect pharmacodynamic effects and confirm target engagement in early brain disease studies
- Identifying biologically responsive patient subgroups to reduce heterogeneity and improve patient selection strategies
- Applying EEG-based responder identification approaches to support go/no-go decisions and progression into larger Phase 2 and 3 studies
- Exploring the role of neurophysiology biomarkers in advancing precision neuroscience and biomarker-informed trial design
