Derek Buhl
Scientific Director AbbVie
Derek Buhl is a Scientific Director in Neuroscience Precision Medicine at AbbVie. He is a neurophysiologist and systems neuroscientist whose work has spanned from running early target discovery projects to implementing end-to-end biomarker strategies for clinical studies in CNS disorders, primarily in schizophrenia, mood disorders, and sleep disorders. His work focuses on the development of translational, circuit-based biomarkers and validation of novel digital tools for remote clinical monitoring to optimize patient stratification, dose rationale, and efficacy measures of pharmacological intervention.
Seminars
- Positioning EEG as a scalable, translational biomarker, integrating neural signals with clinical and biological data to improve patient stratification and development decision-making
- Moving beyond symptom-based diagnoses by leveraging EEG-derived neurophysiological signatures to reduce heterogeneity and define biologically coherent subgroups
- Translating EEG, digital phenotyping, and AI-enabled analytics from research tools into deployable assets across clinical trials, endpoints, and real-world settings
- Aligning pharmacological and non-pharmacological interventions with EEG-informed neural biomarkers to guide target engagement, dose selection, and personalized treatment strategies
- Positioning EEG as a scalable, translational biomarker, integrating neural signals with clinical and biological data to improve patient stratification and development decision making
- Moving beyond symptom based diagnoses by leveraging EEG derived neurophysiological signatures to reduce heterogeneity and define biologically coh erent subgroups
- Translating EEG, digital phenotyping, and AI enabled analytics from research tools into deployable assets across clinical trials, endpoints, and real world settings
- Aligning pharmacological and non pharmacological interventions with EEG informed neural biomarkers to guide target engagement, dose selection, and personalized treatment strategies
- Defining which facets of sleep (onset, maintenance, early awakening, quality, or EEG specific signals) truly matter as clinical biomarkers
- Understanding the practical and scientific limits of EEG in psychiatric sleep research: specificity, invasiveness, and placebo susceptibility
- How sponsors (orexin programs, sleep promoting or circadian targeting drugs) and EEG tech vendors interpret sleep architecture in different disease contexts
- Identifying core unmet needs in insomnia and sleep dysregulation across mood and psychiatric disorders, and what measurement innovation is required
- Defining which facets of sleep (onset, maintenance, early awakening, quality, or EEG specific signals) truly matter as clinical biomarkers
- Understanding the practical and scientific limits of EEG in psychiatric sleep research: specificity, invasiveness, and placebo susceptibility
- How sponsors (orexin programs, sleep promoting or circadian targeting drugs) and EEG tech vendors interpret sleep architecture in different disease contexts
- Identifying core unmet needs in insomnia and sleep dysregulation across mood and psychiatric disorders, and what measurement innovation is required