Connor Maltby
Head of Translational Medicine Ulysses Neuroscience
Seminars
Thursday 17th September 2026
From Synapses to Behaviour: Multidimensional Translational Profiling of Hallucinogenic & Non-Hallucinogenic Neuroplastogens
9:30 am
- Defining novel neuroplastogen signatures: AI-driven multidimensional profiling combining biomarker signatures, ultrasonic vocalisations, head-twitch response and naturalistic behaviour to identify neuroplastogen-specific phenotypes and distinguish hallucinogenic from non-hallucinogenic compounds
- Linking structural plasticity to functional efficacy: Integrating 3D Golgi-based neuronal morphology with synaptic and cytoskeletal biomarkers, neurophysiology and behavioural readouts to determine how structural plasticity translates into functional effects in translational models of depression
- Translating mechanisms across experimental systems: Connecting in vivo neuroplastogen responses with mechanistic screening in primary cortical neurons and human iPSC-derived neurons across molecular, structural and functional endpoints
