Translating Circuit Biology into Biomarkers: Integrating EEG, Electrophysiology, & Neural Signatures in Drug Development
- Leveraging EEG and complementary neurophysiology approaches to map circuit-level modulation and therapeutic mechanisms
- Combining immediate-early-gene readouts, single-unit recordings, and local field potentials to construct multi-modal circuit signatures
- Building translational frameworks that bridge preclinical circuit modulation to human biomarker endpoints
- Advancing biomarker-driven decision-making to de-risk development and guide dose selection, target engagement, and clinical translatability