Genetics‑Anchored Animal Models as a New Foundation for Psychosis Drug Discovery

• Leveraging large‑scale human genetics to define biologically grounded entry points for schizophrenia and bipolar disorder
• Designing next‑generation animal models that capture disease‑relevant circuits and synaptic phenotypes rather than surface behaviors alone
• Using genetically informed models to distinguish causal mechanisms from downstream correlates in psychotic disorders
• How genetics‑anchored models can enable more rational discovery of novel drug targets and translational biomarkers

Speakers:

Zohreh Farsi

Senior Group Leader/ Research Scientist

Broad Institute