Panel Discussion: Ketamine & Rapid Acting Antidepressants: Plasticity, Metabolites & the Next Generation of Therapeutic Innovation

• What emerging preclinical and clinical data reveal about ketamine induced synaptic plasticity as a unifying mechanism for rapid antidepressant effects
• The role of ketamine metabolites, including HNKs, in disentangling efficacy from dissociation and informing more targeted drug design
• Progress toward non dissociative and next generation ketamine derived therapies, and how these may reshape safety, scalability, and patient access
• Lessons from S-ketamine on regulatory pathways, payer expectations, and commercial adoption; and what this means for the broader psychedelic and rapid acting psychiatry landscape

Speakers:

Scott Thompson

Professor, Department of Psychiatry

University of Colorado Anschutz Medical Campus

Marco Pignatelli

Assistant Professor of Psychiatry

WashU Medicine

Zoe Hughes

Vice President Biology & Translational Medicine

Gilgamesh Pharmaceuticals