Translational Pharmacology & Biomarker Development of the Novel α7 nAChR Positive Allosteric Modulator BNC375

Time: 12:15 pm
day: Day One


• α7 positive allosteric modulators (PAMs) exhibit superior efficacy and selectivity to α7 agonists
• BNC375 improves cognitive function in aged African green monkeys which manifest pathological and cognitive hallmarks of Alzheimer’s disease
• BNC375 enhances 13C enrichment in brain metabolites in rat and nonhuman primate cortex following 13C glucose infusion, a novel translation biomarker for the development of α7 PAMs