Thalamo-cortical Dysconnectivity in Schizophrenia & Youth a High Clinical Risk for Schizophrenia

Time: 10:10 am
day: Day Two


• Compared to people unaffected with schizophrenia, people with schizophrenia (SZ) have less connectivity between the thalamus and both frontal lobe areas and cerebellum
• SZ have more hyperconnectivity between thalamus and temporal lobe
• Hypo-connectivity to cerebellum in SZ is related to delusions and bizarre behavior
• Hyper-connectivity to auditory cortex in SZ is related to hallucination and delusion severity
• Youth at clinical high risk for psychosis show a similar pattern of hypoand hyper-thalamo-cortical connectivity